State-of-the-art Therapy for Glioblastoma Multiforme

a report by Henry S Friedman, MD James B Powell Jr Professor of Neuro-oncology, Dukes University Medical Center The treatment of patients with glioblastoma multiforme (GBM) is conventionally considered to be a palliative venture with no hope of cure. Traditionally, patients are treated with maximal surgical resection based on the premise that, although surgery is…

Glioblastoma Multiforme—Past, Present, and Future

The most common cancer arising from the brain is the glioblastoma multiforme (GBM). It is also the most deadly,1 representing the most aggressive subtype among the gliomas, a collection of tumors including astrocytomas and oligodendrogliomas. In 1926, Bailey and Cushing, in describing ‘spongioblastoma multiforme’, the label then used for GBM, noted that: “It is from…